With age, the tissues no longer receive an adequate cell replacement from the stem cells, progressively losing their ability to function properly. Stem cells too age with the organism and for this reason the capacity to regenerate tissues and skin is reduced. On the skin there begins a general process of senescence of the cells forming the epidermis, the dermis, the hair follicle and the stem cells located at these sites. Added to this is the loss of the ability to respond to oxidative stress and environmental damage.
Labo's aim was to intervene in these degenerative processes by means of two types of Active Plant Stem Cells in association with a third molecule to target activity on epidermal, dermal and hair follicle cells.
These are active plant stem cells obtained throuhg a special culture process, from the Malus domestica species, to aid the reproduction of epidermal and dermal cells and their ability to self-renew; from the Buddleja davidii species, to protect all the skin cells against damage caused by oxidation. This protection on the cells is particularly important because, in this way, the cells succeed in keeping their functionality intact, slowing down the process of cell senescence; the Teprenone molecule also acts in the reduction of the length of the cell telomeres which causes less vitality and degradation of the skin. Teprenone, by protecting the telomeres, helps increase cell longevity.
The most recent studies in medicine and biology concern stem cells and their huge potential. Every day new data are acquired and new horizons appear. Also the cosmetics industry has been investigating this sector of research, especially as regards the intrinsic properties of tissue stem cells which consist the human body and the skin.
What are stem cells?
Stem cells are non-specialised cells that renew through cell division for an indefinite period of time. They can become specialised cells of various tissues of the body. Thanks to this property, stem cells are able to replace dead or no longer functioning cells. As known, animal stem cells are found in the embryo and in some tissues of the adult. Depending on where they come from, stem cells are totipotent if they can give rise to any type of tissue or multipotent if they can only become certain tissues (these are adult stem cells).
Plant stem cells
Plants also have Stem Cells, in particular two stem-cell populations: one includes the apical meristem of the shoot and the root and the other consist of the lateral meristem.
Differently from man, adult plants contain totipotent stem cells, this means that each cell has the capacity to generate new organs (leaves, flowers, etc.) or even the whole plant.
More specifically, plant stem cells are undifferentiated plant cells whose sole purpose is reproduction. Therefore, they deal with the reparation and the growth of the plant in length (primary or apical meristem) and in width (secondary meristem). Cell proliferation activity is very intense in these stem cells. The plant stem cells used by Labo derive from explants of plant species put in culture.
On the cut surface of the explant, new cells form for as a scar reaction. These cells divide slowly to form a mass of cells, called a callus.
Why use active plant stem cells for applications to skin and hair? Active plant stem cells contain powerful essential life substances, such as proteins, lipids, carbohydrates, minerals and a fraction of other molecules that can help protect and guarantee the longevity of cutaneous stem cells and of all the cells of the skin and scalp. In cosmetic products they can perform a “restructuring and renewal” action on the epidermis and on the hair follicle, obtaining particularly high synergic effects.
Labo and research studies on plant stem cells
In the last few years, Labo have developed a treatment plan relating to the action of plant stem cells on the skin and on the hair originating from the most important scientific discoveries of recent years regarding stem cells. From the data obtained about the extraordinary characteristics of stem cells, Labo investigators have carried out in-depth research studies and created an original complex of active plant stem cells that, together with preparations for topical use in cosmetics, is ideal for providing a regenerative action and reactivating cell longevity to help skin cell layers.
Stem cells of skin and hair
Over the whole skin of the face and body, distributed in the deep basal layer of the epidermis, there are adult stem cells that are able to become differentiated as they gradually proliferate and become superficial, giving rise to the specialised differentiated cells of the epidermis that form distinct tissue layers: spinous, granular and corneum, the outermost layer. Photo-ageing and time-ageing can damage stem cells, causing a reduction in their population and weakening their functionality. The hair follicle also has a deposit of stem cells able to guarantee continuous cell reproduction. The main reserve of stem cells is found in the bulge area, which is characterised by a kind of swelling located in the erector muscle. Thus stem cells, by continuously renewing the cell content of the epidermis and of the hair follicle, are responsible for the vitality, youthfulness and quality of the skin and hair.