Fillerina 12Ha Densifying-Filler

Filler Effect 12 Hyaluronic Acids with different molecular weights for skin depressions, for the volume of cheekbones and lips.
Densifying Effect 3 Collagens and 2 Elastins to support the skin firmness.

Dermo-Cosmetic Densifying – Filler Treatment for at-home use

Fillerina 12Ha Densifying-Filler

“12Ha” stands for 12 Hyaluronic Acids with different molecular weights that provide a filling effect of wrinkles and expression lines, and a volume effect on specific areas (cheekbones, lips)

Fillerina 12HA Densifying-Filler Dermo-cosmetic Treatment is a preparation for at-home use to be used for 14 days and applied by means of the special applicator with truncated tip. Fillerina Gel formulation associates 12 different types of Hyaluronic Acids with 12 different molecular weights, ranging from 400 to 2.000.000 Dalton, for a modulated filling of the different skin layers (the penetration of the molecules has been tested ex-vivo with Franz Cells). They are associated with 3 Collagens and 2 Elastins having densifying and elasticizing properties.

Fillerina 12Ha Densifying-Filler is available in three different concentrations to be chosen according to skin and wrinkle conditions.

The box contains:
14 doses (2 ml) of Gel Filler

14 doses (2 ml) of Nourishing Film

2 precision applicators


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Fillerina 12Ha Densifying-Filler Day Cream

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Fillerina 12Ha Densifying-Filler Night Cream

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Fillerina 12Ha Densifying-Filler Eye Contour Cream

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Fillerina 12Ha Densifying-Filler Lip Contour Cream

For lips and lip contour, with densifying-filler effect. To be used alone or together with other Fillerina products.

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FILLERINA PRODUCT CONCEPT
Injection dermal fillers based on Hyaluronic Acid are used to fill and give volume to areas of the face showing signs of aging, skin depressions, hollow cheeked facial features, etc. The filling properties of Hyaluronic Acid are based on its strong ability to swell and form inside the skin tissues a soft and easily malleable gel by combining with large quantities of water molecules.

Fillerina was developed to satisfy the need to bring in the deepest layers of the skin important quantities of hyaluronic acid (like the injections of aesthetic medicine) but without the use of a needle and therefore without invasive procedures. To achieve this goal, several researches have been carried during years. As a result, the researchers obtained a diversification of the molecular weights of Hyaluronic Acid so to allow its penetration deep into the skin.

Thanks to this achievement, Fillerina overcomes the standard cosmetic products containing hyaluronic acid, which can claim only a good hydration of the most superficial layers of the skin. Fillerina becomes a real alternative to the aesthetic medicine injections, being able to produce a remarkable filler action on wrinkles and saggings, as well as filling and volumizing particular areas of the face such as cheekbones and lips.


FILLER EFFECT
Fillerina is the first dermo-cosmetic filler treatment to be used at home for external application.

The product name comes from the filling mechanism of face depressions (wrinkles) and from the plumping mechanism of specific zones (in vivo test) thanks to the action of special Hyaluronic Acids with different molecular weights for a different level of filling on expression lines, age wrinkles, microrelief and areas of the face subject to sagging or emptying (cheekbones, around the oval of the face, lips surface).

As skin ages, the amount of Hyaluronic Acid gradually decreases, causing imperfections such as age wrinkles, expression lines and a loss of volume (emptying and skin depressions), especially on cheekbones, cheeks and lips.

Fillerina 12Ha Densifying-Filler features a mix of 12 different Hyaluronic Acid molecules with varying molecular weights and sizes that are especially effective at penetrating the layers of the skin (ex vivo tests with Franz Cells), thus allowing tissues to be filled in and plumped up. Among the Hyaluronic Acids with filler effect contained in this formulation, the 3 new ones, having 20.000, 80.000 and 500.000 Da molecular weights, showed a great penetration capability (ex vivo test).


DENSIFYING EFFECT
Fillerina 12Ha Densifying-Filler associates 3 Collagen molecules with different molecular weights (2.000, 12.000 and 300.000 Da) which, by penetrating up to the dermis (ex vivo test with Franz Cells), can promote an increase in the extracellular matrix density and improve the filling effect, in synergy with Hyaluronic Acid molecules.

With chronological ageing also the quantity and quality of Elastin, the protein that builds up elastic fibres, drastically decreases thus threatening skin plasticity and contributing to skin sagging. The formulation associates 2 molecules of Elastin with different molecular weights (1 400 Da and 2 200 Da), which aim at compensating this loss and restore skin elasticity and plasticity.


ADDITIONAL COMPONENTS
Fillerina Filler Gel is enriched also with additional components that assist the filling and volumizing action of hyaluronic acids, acting more gradually and supporting their biological function at skin level structures: Palmitoyl Tripeptide-38 (Matrifull) and Acetyl Hexapeptide-37. Finally, Chondroitin Sulfate helps create a 3D scaffold with Hyaluronic Acid molecules.

Fillerina 12 Densifying-Filler dermo-cosmetic treatments for at-home use come in three different concentrations, in order to provide the most effective, suitable treatment for the conditions of the skin and the cutaneous tissues of the face and neck and enhance the volume of cheekbones and lips.

 

GRADE 3: Initial wrinkles and expression lines. Initial age wrinkles and uneven microrelief. Initial depression and depletion of the tissues. Skin with decreasing thickness, density and plasticity. Initial sagging signs. Need for more volume to cheekbones and lips.

 

GRADE 4: Deep wrinkles and expression lines. Age wrinkles with visible, marked and uneven microrelief. Conspicuous depression and depletion of the tissues. Skin with poor thickness, density and plasticity. Visible sagging signs. Need for more volume to cheekbones and lips.

 

GRADE 5: Very deep wrinkles and expression lines. Age wrinkles with very marked and uneven microrelief. Severe depression and depletion of the tissues. Skin with insufficient thickness, density and plasticity. Marked sagging signs. Need for more volume to cheekbones and lips.

The skin is hardly permeable: in order for the active ingredients to penetrate the different cutaneous layers, Labo researchers developed a “transdermic” technology based on the very low molecular weight of the active substances. This is the fundamental condition to guarantee their penetration in the cutaneous layers. It is precisely thanks to this controlled penetration that the active ingredients are really effective in terms of filling.

Swiss Patent CH 705 713 B1

Fast-penetration cosmetic dermal filler for topical application.

Swiss Patent CD 695 412 A5


Graduated cosmetic precision applicator with truncated tip.

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