Fillerina Long-Lasting Durable Filler

Long-Lasting Filler Effect: Double concentration of 12 Hyaluronic Acids with differentiated molecular weights for skin depressions (wrinkles and expression lines), for the volume of cheekbones and lips.

Polyglutamic Acid for an anti-hyaluronidase action, to prolong the permanence of Hyaluronic Acids in the skin. Contains anti-collagenases and anti-elastases.

7 Plate-Like Molecules for a Restructuring Effect.

 

Dermo-Cosmetic Filler Treatment for at-home use.

Fillerina Long-Lasting Durable Filler

Long-Lasting Filler Effect dermo-cosmetic treatment for at-home use. With 12 Hyaluronic Acids with differentiated molecular weights; the concentration of 8 of them has been doubled for skin depressions (wrinkles and furrows), for the volume of cheekbones and lips. Polyglutamic Acid for an anti-hyaluronidase action prolongs the permanence of Hyaluronic Acids in the skin. Contains anti-collagenases and anti-elastases and 7 Plate-Like Molecules for a Restructuring Effect.

 

It contains:

7 doses (2ml each) of Filler Gel for 7 days

8 doses (2 ml each) of Filler Gel for 8 weekly recalls

15 doses (2 ml each) of Nourishing Film

2 Precision Applicators for external use


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Fillerina Long-Lasting Durable Filler Day Cream

For a long-lasting restructuring-filler effect. It contributes to prolonging the results of the intensive treatment. Moisturizing and protective, to be used alone or in combination with other Fillerina preparations.

In a 50-ml tube.

Dosages: Grades: 3, 4 and 5.


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Fillerina Long-Lasting Durable Filler Night Cream

For a long-lasting restructuring-filler effect. It contributes to prolonging the results of the intensive treatment. Moisturizing and protective, to be used alone or in combination with other Fillerina preparations.

In a 50-ml tube.

Dosages: Grades: 3, 4 and 5.


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Fillerina Long-Lasting Durable Filler Eye Contour Cream

For a long-lasting restructuring-filler effect on the eye contour. It contributes to prolonging the results of the intensive treatment. To be used alone or in combination with other Fillerina preparations.

In a 15-ml tube.

Dosages: Grades: 3, 4 and 5.


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Fillerina Long-Lasting Durable Filler Lip Contour Cream

For a long-lasting restructuring-filler effect on both lip area and lip contour. It contributes to prolonging the results of the intensive treatment. To be used alone or in combination with other Fillerina preparations.

In a 15-ml tube.


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Fillerina Long-Lasting Durable Filler dermo-cosmetic treatments for at-home use offer diversified mixes of active ingredients, to be chosen according to skin, wrinkles and furrows conditions.
 

 GRADE 3

• Initiali wrinkles and expression lines.

• Initial age wrinkles and uneven microrelief.

• Initial depression and depletion of the tissues.

• Skin with decreasing thickness, density and plasticity.

• Initial sagging signs.

• Need for more volume to cheekbones and lips.


GRADE 4

• Deep wrinkles and expression lines.

• Age wrinkles with visible, marked and uneven microrelief.

• Conspicuous depression and depletion of the tissues.

• Skin with poor thickness, density and plasticity.

• Visible sagging signs.

• Need for more volume to cheekbones and lips.


GRADE 5

• Very deep wrinkles and expression lines.

• Age wrinkles with very marked and uneven microrelief.

• Severe depression and depletion of the tissues.

• Skin with insufficient thickness, density and plasticity.

• Marked sagging signs.

• Need for more volume to cheekbones and lips.

LONG LASTING FILLER EFFECT

In Fillerina Long-Lasting Durable Filler the new treatment methodology involves two phases:

7 Days: 7 doses (2 ml each) of the new Filler Gel are to be applied on the face skin for 7 days. In terms of formulation, it contains 12 hyaluronic acids with different sizes and molecular weights (from 400 to 2 million Dalton), particularly effective in penetrating the skin layers (ex vivo test with Franz Cells) to promote the filling and plumping of the tissues. The concentration of the 8 Hyaluronic Acids with lower molecular weights (from 400 to 100 000 Dalton) has been doubled (+100%) compared to the quantity contained in Fillerina standard formulation. This increase allows the skin to absorb a greater quantity of hyaluronic acid for faster results (7 days). To prolong the permanence of hyaluronic acids in the skin layers, the formula has been modified with the addition of Polyglutamic Acid, which plays a remarkable anti-hyaluronidase activity, i.e. it counteracts the degradation process of the hyaluronic acid molecules once absorbed in the skin.

8 Recalls: after the 7 daily applications of Filler Gel for the first week, results can be prolonged thanks to 8 doses (2 ml each) to be applied as a weekly recall for 8 weeks. This ensures a durable result for several months after the treatment is completed. The formulation of the 8-Recall Filler Gel, too, is based on 12 hyaluronic acids with different sizes and molecular weights (from 400 to 2 million Dalton), particularly effective in penetrating the skin layers (ex vivo test with Franz Cells) to promote the filling and plumping of the tissues. The concentration of the 8 Hyaluronic Acids with lower molecular weights (from 400 to 100 000 Dalton) has been doubled (+100%) compared to the quantity contained in Fillerina standard formulation. In addition to the increased content of Polyglutamic Acid with anti-hyaluronidase action, the 8-Recall Filler Gel contains two new molecules that help prolong the integrity of collagen and elastin fibers contained in the dermis: COL-Peptide (Arginine / Lysine Polypeptide) for an anti-collagenase action, and EL-Peptide (Acetylarginyltryptophyl Diphenylglycine) for an anti-elastase action.


DENSIFYING AND RESTRUCTURING EFFECT

Among the aspects of skin aging is the depletion of two essential substances for skin support: Collagen and Elastin. The loss and both quantitative and qualitative reduction of Collagen and Elastin in the dermis result in a lower thickness, density and plasticity of the extracellular matrix, with subsequent increase in wrinkles, skin depressions and loss of volume. Fillerina Long-Lasting Durable Filler contains 3 Collagen molecules with different molecular weights (2 000, 12 000 and 300 000 Dalton) and 2 Elastin molecules with different molecular weights (1 400 and 2 200 Dalton) which, by penetrating up to the dermis (ex vivo test with Franz Cells), are able to enhance the density and elasticity of the extracellular matrix, improving the filling of the skin in synergy with Hyaluronic Acid molecules. Their permanence within the skin layers is also ensured by the action of specific anti-collagenase and anti-elastase molecules.


Fillerina Long-Lasting Durable Filler formulation contains also the exclusive complex of 7 Plate-Like Molecules, synthetic growth factors similar to endogenous molecules (Synthetic Human Connective Tissue Growth Factor/ sh-Polypeptide-93; Synthetic Human Acidic Fibroblast Growth Factor/sh-Polypeptide-11; Synthetic Human Basic Fibroblast Growth Factor/sh-Polypeptide-1; Synthetic Human Epidermal Growth Factor/sh-Oligopeptide-1; Synthetic Human Keratinocyte Growth Factor/sh-Polypeptide-3; Synthetic Human Transforming Growth Factor Beta-3/sh-Polypeptide-5; Synthetic Human Insulin-Like 1 Growth Factor/sh-Oligopeptide-2) with marked regenerative properties, which make them capable of performing a deep restructuring effect on the skin, while promoting the restoring of skin structures such as collagen fibers, elastic fibers and extracellular matrix.

Additional components: Matrifull, Hexapeptide, Chondroitin Sulfate. Furthermore, 2 peptide molecules (Palmitoyl Hexapeptide-52 and Palmitoyl Heptapeptide-18) promote a decontracting effect on naso-labial and glabellar furrows and on lip contour wrinkles

PHASE 1. Fillerina Long-Lasting Durable Filler Treatment shall start with the application of the 7-Day Filler Gel for 7 days, preferably in the evening, by distributing 2 ml of gel onto wrinkles, on the most marked microrelief, on areas subject to sagging (cheeks, jawline and chin) and on those requiring particular plumpness (cheekbones, lips). To promote the activity of Fillerina, it is recommended to apply the preparation only on clean skin, free from sebum and impurities. The product shall be applied by means of the specific Dispenser/Applicator which allows the user to draw up two separate 1 ml amounts of product (adding up to a total of 2 ml per application) and release them accurately onto the desired areas. The Filler Gel should be left to work for 10 minutes, to let the ingredients “fill in” the areas of application. Then help the penetration of any excess of preparation by tapping with the palms of the hands. Do not carry out rotating massages or movements to prevent the possible formation of surface residues. Any feeling of tension on the skin is due to the action of the product. Then apply the Nourishing Film which guarantees a sufficient amount of moisturizing and nourishing substances, and allows the Gel application to be completed with maximum comfort for the skin of face and neck. Draw up 1 to 2 ml of Film, as needed, and spread it all over face and neck. To facilitate the action of the product, it is advisable to drink two glasses of water before the application of Fillerina Gel.


PHASE 2. After the first week of daily applications, take a week off and resume the weekly applications with the 8-Recall Filler Gel, always choosing the same day of the week for the treatment, for example on Saturdays, preferably in the evening. Instructions on how to use are the same as for the 7-Day Filler Gel, with a 10-minute wait after having distributed the Gel, and the following application of the Nourishing Film to complete each weekly recall. It is recommended to apply Fillerina Long-Lasting Durable Filler daily creams between one recall application and another (see below). The special precision applicators have been patented by Labo and shall be rinsed with lukewarm water and stored after every use.


Do not carry out rotating massages or movements that could compromise the correct penetration of the product.


The possible formation of surface residues similar to shavings (easily removable with fingers or by a powder brush) indicates an excess of product with respect to the subjective need of skin tissue treated. In this case it is advisable to reduce the quantity of Gel (1,5 or 1 ml instead of 2). Any feeling of tension on the skin is due to the action of the active ingredients present in the product.


Fillerina Long-Lasting Durable Filler is a dermo-cosmetic preparation for external use only. Avoid contact with the eyes, do not swallow, do not inject, keep out of the reach of children, keep away from light and heat.

Swiss Patent CH 705 713 B1

Fast-penetration cosmetic dermal filler for topical application.

Swiss Patent CH 695 412 A5


Graduated cosmetic precision applicator with truncated tip.

Swiss Patent CH 711 466

Dermo-cosmetic product for topical application with penetration enhancing properties and process for its production.

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