Labo Hair Loss 5 Patents
HAIR LOSS is defined as the detachment of hair from its follicle.
It is a physiological phenomenon which is part of the normal reproductive cycle of hair.
The life cycle of hair is characterized by precise balances and times. Healthy hair is produced, develops and falls out following three phases: the anagen phase: development and growth of hair (duration of approx. three years); catagen phase: reduction in follicle activity and size (duration approx. three weeks); telogen phase: resting phase (duration approx. three months) culminating in the detachment of hair from its follicle.
On average, it is normal to shed between 50 and 100 hairs per day. If the number of hairs shed exceeds this average, we are dealing with more significant hair loss, where the balance between the various phases of the life cycle of hair has been upset either by seasonal influences or by chronic conditions that lead to progressive thinning.
HAIR LOSS is a regular problem, in both males and in females, alike.
Excessive hair loss may instill a fear, this is perfectly normal and common to many. Usually it is nothing to be worried about, though, actually it can be upsetting.
Causes of sudden hair loss include: change of seasons (spring, autumn), psychological and physical stress, surgery, infectious diseases or fever, significant emotional trauma, weight-loss diets. In women in particular, some factors are linked to natural moments of change for the body: post-natal, breastfeeding.
Persistent or chronic hair loss, meanwhile, can be caused by nutritional deficiencies (e.g. zinc deficiency, insufficient protein intake), aggressive cosmetic treatments (above all in women), chronic stress (anxiety, sleep disorders, depression), chronological aging and, in particular, the effects of shedding caused by androgenetic alopecia.
NEW ANTI-HAIR LOSS FORMULATION IMPROVED BY TRANSDERMIC TECHNOLOGY
Labo Hair Loss 5 Patents is a dermo-cosmetic treatment in vials for topical use that helps stop the hair loss, counteracting the different causes and promoting the anchorage of the hair shaft to the scalp. Labo Hair Loss 5 Patents consists in 5 complexes of active molecules and is protected by 5 Swiss Patents:
1. Anti-Hair Loss Complex (Hydroxyproline, Aspartic Acid, Enzymatic Activator), with Taurine: it has a strengthening effect on the hair follicle sheaths and helps prevent the premature detachment of the hair shaft. Swiss Patent CH 693 817;
2. Scalp and Hair System Anti-Aging Complex (Pentapeptide-28, Hydrolyzed Soy Protein, Myrtus Communis Extract, Teprenone): it helps counteract the causes of aging of the hair system, prolonging the functionality of the hair follicles. Swiss Patent CH 700 735;
3. Protection of Scalp and Hair Follicle Stem Cells Complex (Pentapeptide-31, Hydrolyzed Pea and Laminaria Digitata Extract): it helps maintain the reserve cells of the scalp in good condition, which is fundamental for the health and life of the hair follicles. Swiss Patent CH 704 629;
4. Hair Follicular Islands Complex (Glycogen, Proline, Hydrolyzed Lupine Protein, Glutamylamidoethyl Indole, Baicaline): it promotes the trophism of the follicles belonging to the hair follicular islands (multi-follicle units) to reduce hair loss. Swiss Patent CH 710 438;
5. Transdermic Technology: the formulation takes advantage of the exclusive system based on 3 enhancers (Pentylene, Decylene and Caprylyl Glycol) and on the low molecular weight of the ingredients, to promote their absorption through the particularly thick cutaneous layers of the scalp, helping reduce the hair loss. Swiss Patent CH 711 466.
The female formulation contains also Biotin and Glutamine, nourishing substances for the hair shaft, Polyquaternium-68 helps protect the hair surface and the root of Pueraria mirifica, source of oestrogens, is an additional support to counteract the hair loss.
Labo Hair Loss 5 Patents helps stop the hair loss, preventing and counteracting the physiological, non-pathological causes.
Specific formulations for man and woman.
In order for Labo Hair Loss 5 Patents functional molecules to penetrate the hair system not only through the follicular openings but also through the scalp, Labo researchers developed a “Transdermic” Technology based on the low molecular weight of the active substances that enables them to penetrate into the cutaneous layers of the scalp, thanks also to the presence of 3 enhancers. The percentages reported here below refer to the transdermic penetration of the functional active molecules, in solution, after 24 hours. Transdermic penetration was made possible by the new Labo technology and tested by means of Franz Cells. Swiss Patent CH 711 466.
TRANSDERMIC TECHNOLOGY: HOW IT WORKS
The penetration of the active ingredients through the single follicular ostium allows them to penetrate on a surface equal to 4.6% of the scalp.
The penetration of the active ingredients via intra-cellular and via inter-cellular route (thanks to both the Transdermic Technology and the enhancers) allows to cover the remaining 95.4% of the scalp.
EVALUATION OF THE EFFICACY OF A TOPICAL TREATMENT AS ADJUVANT FOR PREVENTING THE HAIR LOSS
40 male and female volunteers (20+20), aged between 19 and 50 years and suffering from telogen effluvium have been selected.
The volunteers applied the preparation once a day, on alternate days, for 60 consecutive days. At the beginning of study (T0), after 1 month (T30) and after 2 months of treatment (T60), the grade of hair resistance to traction on three selected areas of the scalp was clinically evaluated by means of Pull Test.
The hair resistance to traction was evaluated as the average of the total number of removed hair in all the 3 selected areas.
Furthermore, the count of the hair lost after washing the scalp in standard conditions was performed by means of Wash Test. After washing, the number of hair left in the sink was counted.
Pull Test Results
After 1-month treatment an increase of 50,48% in the hair resistance to traction was detected compared to T0, and after 2 months an increase of 89,32% in hair resistance to traction compared to T0. The increase in hair resistance to traction was statistically significant both in the middle and at the end of the treatment (Graph 1).
Wash Test Results
After 1-month treatment a decrease of 36.25% in the number of hair lost during the wash test was detected compared to T0, and after 2 months a reduction of 49.72% in the number of hair lost compared to T0. The decrease in the number of hair lost during the wash test was statistically significant both in the middle and at the end of the treatment (Graph 2).
During the treatment and at the end of the study, volunteers observed a decrease in the hair loss, a decrease in their seborrhoea and sebum level of the hair, together with a good tolerance of the preparation.
It is recommended to apply a vial on alternate days. The pack allows for a 4-week treatment.
HOW TO USE
Labo Hair Loss 5 Patents contains 14 vials. Each vial contains 3.5 ml of product and is suitable for an alternate daily use.
SWISS PATENT CH 704 629 B1
Cosmetic composition for activating the epidermis and dermis stem cells and their microenvironment.
Swiss patent CH 710 438
Cosmetic formulation for the treatment of the Hair Follicular Islands of the scalp
Swiss Patent CH 711 466
Dermo-cosmetic product for topical application with penetration enhancing properties and process for its production.
SWISS PATENT CH 693 817
Anti-Hair Loss. Preparation for topical application for combating hair loss.
EUROPEAN PATENT EP 1 646 359
Anti-Hair Loss. Preparation for topical application for combating hair loss.
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