CLINICAL-INSTRUMENTAL STUDY
OF COLLAGENINA EFFECTIVENESS
Collagenin is a plumping and firming dermal treatment for at-home use with 6 Collagens with different molecular weights inspired by Labo’s patented Transdermic Technology. it contrast
the sagging of the skin tissues of the face.
CLINICAL-INSTRUMENTAL STUDY OF THE PLUMPING AND FIRMING EFFICACY OF A DERMAL-COSMETIC TREATMENT FOR FACE SKIN: COLLAGENINA FACE PACK WITH 6 COLLAGENS FOR IN-DEPTH FAST PENETRATION
The study aims to evaluate the efficacy of a cosmetic facial treatment in improving parameters related to skin aging such as skin ptosis, microrelief and micro-wrinkles. In order to reach this goal, a clinical study is carried out on 20 healthy female subjects, aged between 35 and 60 years old, showing sagging/ptosis of the lower part of the face (sagging jowls), marked microrelief and micro-wrinkles. Treatment efficacy is assessed after 7 and 14 days of products use by means of non-invasive image analysis. Moreover, at the end of the study, subjects are asked to express their opinion on tested treatment acceptability and efficacy by answering to a self-assessment questionnaire.
1) SKIN THICKNESS AND SKIN DENSITY (SKIN PLUMPNESS) WERE DETERMINED BY MEANS OF CHEEK ULTRASOUND.
The ultrasound allows to assess the echogenicity and to measure the skin thickness (epidermis + dermis). These parameters are related to the organization of the extracellular matrix (dermis) and are influenced by photoageing, chronoageing, and the water content of the skin. Skin thickness is measured in five points (white dotted lines) all over the analysed skin section; while echogenicity improvement is scored as an increase of the colours’ distribution inside the analysed skin section.
Skin Thickness Results
• +7.1% after 7 days and +14.9% after 14 days
• 95% of the subjects improved after 7 days
• 100% of the subjects improved after 14 days
Skin Density Results
• 8.9% after 7 days and +15.5% after 14 days
• 80% of the subjects improved after 7 days
• 100% of the subjects improved after 14 days
2) ASSESSMENT OF THE REMODELLING EFFECT ON FACE CONTOUR
The evaluation of the remodelling effect on the face contours is carried out by means of morphometric image analysis run out on the lateral digital photographic image of the face acquired before and after products use. A decrease of the measured distance indicates a remodelling.
Reshaping Effect Results
• -0.63 mm after 7 days and -1.15 mm after 14 days
• 85% of the subjects improved after 7 days
• 91.7% of the subjects improved after 14 days
3) SKIN PROFILOMETRY
Skin surface is quantitatively assessed by Primos 3D (GFMesstechnik GmbH). Primos 3D is a non-contact in vivo skin measurement device based on structured light projection. In conjunction with a comprehensive 3-D measurement and evaluation software, the sensor allows to evaluate skin surface properties (i.e. wrinkle depth, volume, skin roughness, etc.). In this study Sa parameter (skin profilometry) is calculated on the cheek.
Skin profilometry results
• -5.4% after 7 days and -9.8% after 14 days
• 90% of the subjects improved after 7 days
• 100% of the subjects improved after 14 days
4) Collagenina treatment self-assessment test
At the end of the study, subjects are asked to express their opinion on the tested product by replying to a self-assessment questionnaire. For the self-assessments, judgment is expressed as “Yes” / “No”.
Does the treatment improve skin firmness? YES 95% – NO 5%
Does the treatment reduce the sagging skin on the face? YES 85% – NO 15%
Does the treatment reduce the visibility of wrinkles? YES 85% – NO 15%
Does the treatment improve skin smoothness? YES 95% – NO 5%
Are you satisfied with the effect obtained using the products? YES 90% – NO 10%
Would you recommend the use of the products for their characteristics? YES 90% – NO 10%
Finally, the product has been judged positively by most subjects (≥85%) for all investigated aspects related to efficacy: skin firmness, visibility of wrinkles, skin smoothness, facial skin relaxation.