Crescina

Crescina Transdermic HFSC
Re-Growth

  • For thinning hair
  • It helps promote the physiological hair growth
  • Effective in 100% of the subjects tested*

Crescina is the first dermo-cosmetic treatment in vials able to address the hair thinning phenomenon. Thanks to the patented Transdermic Technology, Crescina relaunches the physiological hair growth on the thinned areas of the scalp, by acting efficaciously on the hair follicles that are not completely atrophied.

Crescina Transdermic HFSC concentrates in one single vial Labo’s expertise and cutting-edge technology: the Re-Growth Complex supports the production of new hair shafts, the HFSC Complex protects the hair stem cells, the new Re-Growth Booster Complex strengthens both hair and follicle and considates the activities of the previous complexes, 3 enhancers improve and facilitate the activity of the active ingredients.

With specific formulations for Man and for Woman, it is available in three different dosages to be chosen according to the stage of thinning. Dermatologically tested formula.

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A SPECIFIC ANSWER TO THE THINNING PROBLEM

A concentrate of innovation dedicated to natural hair growth.

Modulo_Grid_Crescina

EFFECTIVE IN 100% OF THE SUBJECTS TESTED*

From +7 to +41 new hairs growing in 1.8 cm².**

*Result after 4 months of in vivo clinical/instrumental double-blind testing, randomized and controlled with a placebo on 46 subjects (23 treated with Crescina HFSC and 23 with the placebo). The male subjects presented levels of thinning at grades II, III, III vertex and IV of the Hamilton-Norwood scale.

**All of the subjects recorded positive results from a minimum of +7 to a maximum of +41 new hairs growing in an area subject to an electronic count of 1.8 cm². The results of the test are statistically significant.



HOW TO FIND THE MOST SUITABLE TREATMENT?

Check the table to know your stage of thinning and find the dosage that best suits your needs.

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THINNING SCALE - WOMAN

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THINNING SCALE - MAN


CR HFSC
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TECHNOLOGY BEHIND EFFECTIVENESS

Thanks to the Transdermic Technology (Swiss Patent CH 711 466) - inspired by the methodology of aesthetic medicine and patented in 2015 - Labo overcomes the frontiers of the dermo-cosmetic science becoming the first company to develop a new technique of penetration of active ingredients, without injections, and through epidermis and dermis.


3 USEFUL TIPS

  1. A treatment of at least two months is recommended, to be repeated twice a year. Where needed, even more cycles can be done, with a month of stop between them.

  2. Apply Crescina on healthy and dry hair scalp.

  3. In the absence of excess sebum, wash your hair at your usual frequency.

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HOW TO USE THE VIAL

Apply one vial a day for 5 consecutive days on dry hair and follow with a two-day break. Do not rinse.
FOR EXTERNAL USE ONLY. DO NOT INJECT. DO NOT SWALLOW.

Illustrazione 1

1. Take the special rigid plastic vial breaker from its holder in the pack.

Illustrazione 2

2. Fit the vial breaker to the vial, simply positioning it over the neck. Grip the vial breaker between finger and thumb and snap off the top part of the vial, applying light but firm pressure.

Illustrazione 3

3. Take the applicator nozzle from its holder.

Illustrazione 4

4. Fit the applicator onto the neck of the opened vial.

Illustrazione 5

5. Remove the cap from the applicator.

Illustrazione 6

6. Apply the preparation to a dry and clean scalp, line by line, concentrating on the areas where thinning is most noticeable. Massage gently to help its penetration.

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Description and INCI

CRESCINA TRANSDERMIC RE-GROWTH

Crescina Transdermic HFSC includes the basic formulation of Crescina Re-Growth HFSC – protected by several patents – combining two amino acids, Cysteine and Lysine (basic components responsible for hair keratinization processes) with a Glycoprotein and a vasodilator component inserted in a hydroalcoholic vehicle: numerous efficacy tests indicate the ability of this association to stimulate natural hair growth by acting on bulbs that are still active or partially inactive, but not completely atrophied. In particular, the formula is characterized by the HFSC complex (Stem-Engine with Hydrolyzed Rice Protein and Corosolic Acid), that helps protect the niche of the hair follicle stem cells for triggering new hair growth.
The formula has been recently improved thanks to the introduction of Labo's patented Transdermic Technology, which allows the active ingredients to penetrate the different layers of skin and scalp, and to the Booster Complex, which provides the cells of the hair bulbs with molecules that help the hair growth process. Finally, 3 enhancers improve and facilitate the activity of the active ingredients.

Suitable for hair thinning dependent on physiological (not pathological) causes, it does not act on completely atrphied hair follicles. For further information, see the internal leaflet.

INCI

Crescina Transdermic HFSC - 200 - Man
ALCOHOL DENAT., AQUA, GLYCERIN, GLYCINE, METHIONINE, ACETYL CYSTEINE, BENZYL NICOTINATE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL, BUTYLENE GLYCOL, DECYLENE GLYCOL, LYSINE HCL, BENZOPHENONE-4, LAMINARIA DIGITATA EXTRACT, MENTHOL, SILANEDIOL SALICYLATE, TRIETHANOLAMINE, HYDROXYPROPYL CYCLODEXTRIN, THREONINE, SERINE, HYDROLYZED PEA, ZINC ACETYLMETHIONATE, PHOSPHATIDYLCHOLINE, HYDROLYZED RICE PROTEIN, PROPYLENE GLYCOL, ADENOSINE, HEMATITE EXTRACT, HYDROLYZED SOY PROTEIN, GLYCOPROTEINS, ERIOBOTRYA JAPONICA LEAF EXTRACT, HYDROLYZED DNA, HYDROLYZED RNA, GLYCINE SOJA (SOYBEAN) OIL, SODIUM OLEATE, GLUTAMIC ACID, COPPER TRIPEPTIDE-1, ARTEMIA EXTRACT, VALINE, PENTAPEPTIDE-31, HYDROGENATED LECITHIN, DISODIUM EDTA, SORBIC ACID, TRISODIUM EDTA, SODIUM HYDROXIDE, POTASSIUM SORBATE, PHENOXYETHANOL, SODIUM METABISULFITE, ETHYLHEXYLGLYCERIN, SALICYLIC ACID, SODIUM BENZOATE, CI 14720, CI 16255, CI 19140, CI 28440, CI 73015.

Crescina Transdermic HFSC - 200 - Woman
ALCOHOL DENAT., AQUA, GLYCERIN, GLYCINE, METHIONINE, BENZYL NICOTINATE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL, BUTYLENE GLYCOL, DECYLENE GLYCOL, BENZOPHENONE-4, ACETYL CYSTEINE, LYSINE HCL, LAMINARIA DIGITATA EXTRACT, MENTHOL, POLYQUATERNIUM-68, SILANEDIOL SALICYLATE, GLUTAMINE, TRIETHANOLAMINE, HYDROXYPROPYL CYCLODEXTRIN, THREONINE, SERINE, HYDROLYZED PEA, BIOTIN, ZINC ACETYLMETHIONATE, PHOSPHATIDYLCHOLINE, HYDROLYZED RICE PROTEIN, PROPYLENE GLYCOL, ADENOSINE, HEMATITE EXTRACT, HYDROLYZED SOY PROTEIN, PUERARIA MIRIFICA ROOT EXTRACT, GLYCOPROTEINS, ERIOBOTRYA JAPONICA LEAF EXTRACT, HYDROLYZED DNA, HYDROLYZED RNA, GLYCINE SOJA (SOYBEAN) OIL, SODIUM OLEATE, GLUTAMIC ACID, HYDROGENATED LECITHIN, COPPER TRIPEPTIDE-1, ARTEMIA EXTRACT, PENTAPEPTIDE-31, VALINE, SODIUM METABISULFITE, ETHYLHEXYLGLYCERIN, SORBIC ACID, TRISODIUM EDTA, PHENOXYETHANOL, DISODIUM EDTA, SODIUM HYDROXIDE, POTASSIUM SORBATE, SALICYLIC ACID, SODIUM BENZOATE, CI 14720, CI 16255, CI 19140, CI 28440, CI 73015.

Crescina Transdermic HFSC - 500 - Man
ALCOHOL DENAT., AQUA, GLYCERIN, GLYCINE, METHIONINE, LYSINE HCL, BENZYL NICOTINATE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL, BUTYLENE GLYCOL, ACETYL CYSTEINE, DECYLENE GLYCOL, BENZOPHENONE-4, LAMINARIA DIGITATA EXTRACT, GLYCYRRHETINIC ACID, MENTHOL, SILANEDIOL SALICYLATE, HYDROXYPROPYL CYCLODEXTRIN, TRIETHANOLAMINE, THREONINE, SERINE, HYDROLYZED PEA, ALLANTOIN, PROPYLENE GLYCOL, ADENOSINE, ZINC ACETYLMETHIONATE, HYDROLYZED RICE PROTEIN, HEMATITE EXTRACT, PHOSPHATIDYLCHOLINE, GLYCOPROTEINS, HYDROLYZED DNA, HYDROLYZED RNA, ERIOBOTRYA JAPONICA LEAF EXTRACT, GLYCINE SOJA (SOYBEAN) OIL, SODIUM OLEATE, GLUTAMIC ACID, ARTEMIA EXTRACT, COPPER TRIPEPTIDE-1, VALINE, PENTAPEPTIDE-31, HYDROLYZED SOY PROTEIN, HYDROGENATED LECITHIN, SODIUM METABISULFITE, SORBIC ACID, ETHYLHEXYLGLYCERIN, TRISODIUM EDTA, PHENOXYETHANOL, SODIUM BENZOATE, SALICYLIC ACID, DISODIUM EDTA, SODIUM HYDROXIDE, POTASSIUM SORBATE, CI 14720, CI 16255, CI 19140, CI 28440, CI 73015.

Crescina Transdermic HFSC - 500 - Woman
ALCOHOL DENAT., AQUA, GLYCERIN, GLYCINE, METHIONINE, BENZYL NICOTINATE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL, BUTYLENE GLYCOL, DECYLENE GLYCOL, LYSINE HCL, BENZOPHENONE-4, LAMINARIA DIGITATA EXTRACT, GLYCYRRHETINIC ACID, MENTHOL, POLYQUATERNIUM-68, SILANEDIOL SALICYLATE, GLUTAMINE, TRIETHANOLAMINE, HYDROXYPROPYL CYCLODEXTRIN, THREONINE, SERINE, HYDROLYZED PEA, ALLANTOIN, BIOTIN, PROPYLENE GLYCOL, ACETYL CYSTEINE, ADENOSINE, ZINC ACETYLMETHIONATE, HYDROLYZED RICE PROTEIN, HEMATITE EXTRACT, PHOSPHATIDYLCHOLINE, HYDROLYZED SOY PROTEIN, GLYCOPROTEINS, PUERARIA MIRIFICA ROOT EXTRACT, HYDROLYZED DNA, HYDROLYZED RNA, ERIOBOTRYA JAPONICA LEAF EXTRACT, SODIUM OLEATE, GLUTAMIC ACID, ARTEMIA EXTRACT, COPPER TRIPEPTIDE-1, PENTAPEPTIDE-31, GLYCINE SOJA (SOYBEAN) OIL, HYDROGENATED LECITHIN, VALINE, ETHYLHEXYLGLYCERIN, SODIUM METABISULFITE, DISODIUM EDTA, SORBIC ACID, PHENOXYETHANOL, POTASSIUM SORBATE, TRISODIUM EDTA, SODIUM HYDROXIDE, SALICYLIC ACID, SODIUM BENZOATE, CI 14720, CI 16255, CI 19140, CI 28440, CI 73015.

Crescina Transdermic HFSC - 1300 - Man
ALCOHOL DENAT., AQUA, GLYCERIN, GLYCINE, METHIONINE, LYSINE HCL, BENZYL NICOTINATE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL, BUTYLENE GLYCOL, ACETYL CYSTEINE, DECYLENE GLYCOL, BENZOPHENONE-4, LAMINARIA DIGITATA EXTRACT, GLYCYRRHETINIC ACID, MENTHOL, SILANEDIOL SALICYLATE, HYDROXYPROPYL CYCLODEXTRIN, TRIETHANOLAMINE, THREONINE, SERINE, PROPYLENE GLYCOL, HYDROLYZED PEA, ADENOSINE, ALLANTOIN, ZINC ACETYLMETHIONATE, HEMATITE EXTRACT, HYDROLYZED RICE PROTEIN, POTASSIUM SORBATE, PHOSPHATIDYLCHOLINE, HYDROLYZED SOY PROTEIN, GLYCOPROTEINS, HYDROLYZED DNA, HYDROLYZED RNA, ERIOBOTRYA JAPONICA LEAF EXTRACT, GLYCINE SOJA (SOYBEAN) OIL, SODIUM OLEATE, GLUTAMIC ACID, HYDROGENATED LECITHIN, ARTEMIA EXTRACT, PENTAPEPTIDE-31, COPPER TRIPEPTIDE-1, VALINE, DISODIUM EDTA, SODIUM HYDROXIDE, ETHYLHEXYLGLYCERIN, PHENOXYETHANOL, TRISODIUM EDTA, SODIUM METABISULFITE, SORBIC ACID, SALICYLIC ACID, SODIUM BENZOATE, CI 14720, CI 16255, CI 19140, CI 28440, CI 73015.

Crescina Transdermic HFSC - 1300 - Woman
ALCOHOL DENAT., AQUA, GLYCERIN, GLYCINE, METHIONINE, BENZYL NICOTINATE, PENTYLENE GLYCOL, CAPRYLYL GLYCOL, BUTYLENE GLYCOL, LYSINE HCL, DECYLENE GLYCOL, ACETYL CYSTEINE, DISODIUM EDTA, BENZOPHENONE-4, LAMINARIA DIGITATA EXTRACT, GLYCYRRHETINIC ACID, MENTHOL, POLYQUATERNIUM-68, SILANEDIOL SALICYLATE, GLUTAMINE, HYDROXYPROPYL CYCLODEXTRIN, TRIETHANOLAMINE, THREONINE, SERINE, PROPYLENE GLYCOL, HYDROLYZED PEA, ADENOSINE, ALLANTOIN, BIOTIN, ZINC ACETYLMETHIONATE, HEMATITE EXTRACT, HYDROLYZED RICE PROTEIN, PHOSPHATIDYLCHOLINE, HYDROLYZED SOY PROTEIN, GLYCOPROTEINS, HYDROLYZED DNA, HYDROLYZED RNA, PUERARIA MIRIFICA ROOT EXTRACT, ERIOBOTRYA JAPONICA LEAF EXTRACT, GLYCINE SOJA (SOYBEAN) OIL, SODIUM OLEATE, GLUTAMIC ACID, ARTEMIA EXTRACT, COPPER TRIPEPTIDE-1, PENTAPEPTIDE-31, HYDROGENATED LECITHIN, ETHYLHEXYLGLYCERIN, VALINE, SODIUM METABISULFITE, SORBIC ACID, PHENOXYETHANOL, TRISODIUM EDTA, SODIUM HYDROXIDE, SALICYLIC ACID, POTASSIUM SORBATE, SODIUM BENZOATE, CI 14720, CI 16255, CI 19140, CI 28440, CI 73015.


The active ingredients of Labo products may be subject to possible modifications. For an updated version, before using the product, read the list of ingredients on the package.

Technology

TRANSDERMIC TECHNOLOGY

In order for Crescina functional molecules to penetrate the hair system not only through the follicular openings but also through the scalp, Labo researchers developed a “Transdermic” Technology based on the very low molecular weight of the active substances and on the presence of enhancers, thanks to their penetration into the scalp skin layers.

Crescina Transdermic HFSC is a topical treatment for cosmetic use that promotes the physiological hair growth.
Thanks to the Transdermic Technology, the active substances of Re-Growth and HFSC Complexes can penetrate through the hair system not only via trans-follicular route (follicle opening) but also through the scalp skin layers (ex vivo test with Franz Cells) assisted by both their low molecular weight and the presence of 3 enhancers (Pentylene Glycol, Decylene Glycol, Caprylyl Glycol), Swiss Patent CH 711 466.

The percentages reported here below refer to the transdermic penetration of the functional active molecules, in solution, after 24 hours. Transdermic penetration was made possible by the new Labo technology and tested by means of Franz Cells.

Acetyl Cysteine

56.70%

Lysine Hydrochloride

58.30%

Glycoproteins

82.40%

Corosolic Acid

76.90%

Hydrolyzed Rice Protein

84.40%

Methionine

52.30%

Glycine

75.90%

Copper Tripeptide-1

77.00%

How to use

HOW TO USE

1. Take the special rigid plastic vial breaker from its holder in the pack.

2. Fit the vial breaker to the vial, simply positioning it over the neck. Grip the vial breaker between finger and thumb and snap off the top part of the vial, applying light but firm pressure.

3. Take the applicator nozzle from its holder.

4. Fit the applicator onto the neck of the opened vial.

5. Remove the cap from the applicator.

6. Apply the preparation to a dry and clean scalp, line by line, concentrating on the areas where thinning is most noticeable. Massage gently to help its penetration.



Crescina Transdermic Re-Growth HFSC vials contain 3,5 ml of the preparation and are suitable for a daily use during the first 5 days of the week, followed by a 2-day break. The 20 vials included in the box allow for a 1-month treatment.

Warnings: For external use only. Do not inject. Do not swallow. Avoid contact with the eyes and the mucous membranes.

Patents

SWISS PATENT CH 703 390

Trichological lotion for topical use activating the hair follicle stem cells to stimulate the physiological hair growth.

EU PATENT EP 2 561 858

Trichological lotion for topical use activating the hair follicle stem cells to stimulate the physiological hair growth.

SWISS PATENT CH 693 814

Trichological lotion for topical use to stimulate the hair growth and to increase the hair shaft thickness.

SWISS PATENT CH 693 815

Trichological lotion for topical use to stimulate the hair growth with extended action.

SWISS PATENT CH 697 229

Trichological lotion for topical use activating the hair follicle stem cells to stimulate the physiological hair growth.

SWISS PATENT CH 711 466

Dermo-cosmetic product for topical application with penetration enhancing properties and process for its production.

Frequent questions

Can I use Crescina treatment during pregnancy/breastfeeding?

Crescina can be used during pregnancy/breastfeeding. However, because of the peculiarities of this particular physiological condition, Labo usually recommends to inform your doctor about the treatment application.

Can I dye my hair during the treatment?

In order not to stress too much the scalp, it is advisable to suspend the treatment when you dye your hair and to resume the application from the day after.

Is Crescina treatment compatible with other hair products like conditioner or hair spry?

Sure, there are no incompatibilities at all.

Do I need to buy a shampoo of the same products?

It is not essential to buy a shampoo of the same line. It is important, however, to use a mild shampoo: from this point of view, Crescina shampoo guarantees the maximum quality.

How long does the treatment last?

The minimum period of application is 2 months, although it is usually recommended to apply the treatment for at least 3/4 months.

Is it normal to feel a slight itching sensation once the product has been applied on the scalp?

Absolutely yes. The preparation contains a mild vasodilator that may cause a slight heat reaction with reddening of the skin for a short time.

How old should I be to start using Crescina?

Considering the hydroalcoholic-based formula of the treatment and the presence of a topical vasodilator that can cause a slight reddening on the skin, for prudential purposes we would recommend the use of Crescina only since legal age.

How do I apply Crescina Treatment?

Crescina should be applied on dry and clean hair (in the morning or evening, depending on your preference) and left to act until the next washing, preferably recommended not earlier than 24 hours since the application.

Where can I find more information regarding the effectiveness of Crescina?

Crescina makes use of numerous tests. Springer’s authoritative journal “Dermatology and Therapy” has published a study that the researchers of Pavia University Department of Biology and Biotechnologies carried out on Crescina HFSC. The study is available on Open Access.

How soon, after the star of Crescina treatment application, results will begin to be visible?

Results depend on the individual conditions. According to the test published in "Dermatology and Therapy", 95.7% of the subjects obtained positive results in terms of new hair growth after 2 months of treatment, 100% of the subjects obtains results in terms of new hair growth after 4 months of treatment.

Why does Crescina preparation not report the expiry date on the packaging?

The PaO (Period After Opening) symbol must be reported on the labelling of all cosmetic products, except for those having a minimum durability of less than 30 months, that will therefore report the caption “Best before…”; single-dose products (such as Crescina vials).

How to choose between Crescina Re-Growth and Crescina Hair Follicular Islands?

Crescina Re-Growth is suitable for those people with thinning hair problems, and in particular for those approaching the Treatment for the first time. Crescina Hair Follicular Islands, instead, is normally recommended for those people who already used Crescina, for a greater activity on the Follicular Islands and not only on the single hair follicles. Crescina Re-Growth is also recommended for the maintenance (1 or 2 vials per week after the 2-month cycle) while Crescina Hair Follicular Islands is a treatment for those who are more inclined to news and scientific discovery.

What are the differences between Crescina vials for women and for men?

Crescina Man and Woman preparations differ since the formulas are specifically designed for the hair characteristics of the two sexes. For example, men's vials contain a lower quantity of emollient substances as their hair is usually oilier than women's hair, who, on the other hand - by virtue of straighteners, hairdryers and dyes - have drier hair. It is therefore preferable that men use men's vials, while women use women’s vials, although, as you can easily imagine, there is no harm in case of reverse use.

Are Crescina preparations always effective?

The essential condition for Crescina preparations to act effectively is that the bulbs inside the hair follicles are not completely atrophied. Thinning must be caused by physiological and non-pathological causes, such as cicatricial alopecia, alopecia areata, etc. In addition, the product must be used for a period of not less than 2 months.

Crescina preparations contain a mild topical vasodilator. Is it possible that the application of Crescina causes an alteration in blood pressure?

Absolutely not. Crescina is a cosmetic product and does not enter the circulation but performs an external localized action. The topical vasodilator is useful for reactivating the superficial microcirculation in the scalp.

Does Crescina weigh hair down?

No, as it contains a hydroalcoholic base that dries quickly and leaves the hair not greasy nor heavy.

Do I always have to wash my hair before applying Crescina?

We suggest to apply the preparation on a clean and dry scalp in order to facilitate the penetration of the active ingredients. However, it is not necessary to wash your hair every day, unless the scalp is particularly oily or with dandruff.

Does the treatment also affect atrophied follicles?

The Crescina treatment can act on dormant but not completely atrophied follicles.
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