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Fillerina

Fillerina

Patent

Fillerina 12HA Biorevitalizing Densifying-Filler Intensive Treatment

  • Biorevitalizing Effect with 20 Amino Acids, 11 Vitamins, 6 Trace Elements and 2 Nucleic Acids.
  • Filler Effect for skin depressions, for the volume of cheekbones and lips.
  • Densifying Effect to support the skin firmness.

Fillerina 12 HA Biorevitalizing Densifying-Filler is the first dermo-cosmetic filler treatment to be used at home for external application. Shall be used every day for 14 days, in the morning or evening, depending on individual needs and habits. The application shall be performed by means of the special Dispenser/Applicator, which allows to draw up a specific amount of product and accurately release it onto those targeted areas such as age wrinkles and expression lines or onto cheekbones and lips to obtain more volume.

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BIOREVITALIZING DENSIFYING-FILLER TREATMENT FOR AT-HOME USE

A dermo-cosmetic alternative to the aesthetic medicine injections

FILLERINA_12HA_INT_Blocco_Hero_Trattamento

DERMO-COSMETIC BIOREVITALIZING DENSIFYING-FILLER TREATMENT TO BE USED AT HOME

First filler treatment for external application

Biorevitalizing Effect: Biorevitalizing Effect with 20 Amino Acids, 11 Vitamins, 6 Trace Elements and 2 Nucleic Acids.
Filler Effect: 12 Hyaluronic Acids with different molecular weights for skin depressions, for the volume of cheekbones and lips.
Densifying Effect: 3 Collagens and 2 Elastins to support the skin firmness.



HOW TO FIND THE MOST SUITABLE TREATMENT?

Fillerina dermo-cosmetic treatments for at-home use come in 3 different concentrations, to be chosen according to skin and wrinkle conditions.

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DERMO-COSMETIC FILLER FOR AT-HOME USE

Fillerina is the 14-day treatment that goes straight to the problem: correct aging signs thanks to the filling properties of the Hyaluronic Acids.

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3 USEFUL TIPS

  1. To facilitate the action of the preparations, drink 2 glasses of water before the application of Fillerina Gel.

  2. Use Fillerina only on clean skin, free from sebum and impurities.

  3. Repeat the treatment several times a year.

WATER

THE BEST FILLERINA ROUTINE

  1. Support the action of the intensive treatment with the maintenance cream

    Fillerina 12HA Biorevitalizing Densifying-Filler
    Day Cream

  2. Extend both filler and densifying effect using the mask

    Fillerina 12HA Biorevitalizing Densifying-Filler
    Night Cream

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Description and INCI

FILLERINA 12HA BIOREVITALIZING DENSIFYING-FILLER
Intensive Treatment

Fillerina 12HA Biorevitalizing Densifying-Filler features a mix of 12 different Hyaluronic Acid molecules with varying molecular weights and sizes that are especially effective at penetrating the layers of the skin (ex vivo tests with Franz Cells), thus allowing tissues to be filled in and plumped up. The molecular weights of the 12 Hyaluronic Acids with filling effect contained in this formulation range from 400 to 2000000 Dalton, and up to a Crosspolymer molecule, and all of them showed a great penetration capability (ex vivo test).
Fillerina 12HA Biorevitalizing Densifying-Filler associates also 3 Collagen molecules with different molecular weights (2 000, 12 000 and 300 000 Da) which, by penetrating up to the dermis (ex vivo test with Franz Cells), can promote an increase in the extracellular matrix density and improve the filling effect, in synergy with Hyaluronic Acid molecules. With chronological ageing also the quantity and quality of Elastin, the protein that builds up elastic fibres, drastically decreases thus threatening skin plasticity and contributing to skin sagging. The formulation associates 2 molecules of Elastin with different molecular weights (1 400 Da and 2 200 Da), which aim at compensating this loss and restore skin elasticity and plasticity.

The Biorevitalizing Effect is obtained thanks to the complex of 20 Amino Acids (with very low molecular weights, ranging from 75 to 204 Dalton), 11 Vitamins (Vitamin A, C, E and B, with molecular weights ranging from 122 to 1500 Dalton), 6 Trace Elements (Calcium, Iron, Magnesium, Manganese, Copper and Zinc with molecular weights ranging from 95 to 162 Dalton) and 2 Nucleic Acids, Hydrolyzed DNA and RNA (660 to 330 Dalton). This complex has all the necessary components for the vitality of the skin, which experiences, as time goes by, a drastic reduction in physiological processes, typical of an old skin. The Biorevitalizing complex is contained in both Gel and Film preparations and aims at stimulating the skin cellular reactivation to help it regain brightness, compactness, smoothness and splendor.

INCI

Fillerina 12 Biorevitalizing HA Densifying-Filler - Gel
Aqua, Glycerin, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate, Carbomer, Caprylyl Glycol, 1,2-Hexanediol, Propylene Glycol, Pentylene Glycol, Sodium PCA, Butylene Glycol, Sodium Hydroxide, Sodium Lactate, Hydrolyzed Elastin, Sodium Hyaluronate Crosspolymer, Arginine, Disodium EDTA, Aspartic Acid, Hydrolyzed Hyaluronic Acid, PCA, Hyaluronic Acid, Hydrolyzed Collagen, Hydroxypropyl Cyclodextrin, Hydrolyzed DNA, Hydrolyzed RNA, Phenoxyethanol, Hydrolyzed Sodium Hyaluronate, Glycine, Alanine, Decylene Glycol, Serine, Valine, Xanthan Gum, Tropolone, Isoleucine, Proline, Threonine, Leuconostoc/Radish Root Ferment Filtrate, Histidine, Phenylalanine, Sodium Chondroitin Sulfate, Soluble Collagen, Sorbic Acid, Glyceryl Caprylate, Palmitoyl Tripeptide-38, Calcium Chloride, Cupric Chloride, Ferric Chloride, Magnesium Chloride, Manganese Chloride, Zinc Chloride, Phenylpropanol, Palmitoyl Hexapeptide-52, Glycolic Acid, Polyvinyl Alcohol, Acetyl Hexapeptide-37, Acetyl Cysteine, Biotin/Folic Acid/Cyanocobalamin/Niacinamide/Pantothenic Acid/Pyridoxine/Riboflavin/Thiamine/Yeast Polypeptide, Glutamic Acid, Glutamine, Leucine, Lysine HCl, Methionine, Palmitoyl Heptapeptide-18, Taurine, Tryptophan, Tyrosine, Sorbitol, Lecithin, Tocopheryl Acetate, Glyceryl Linoleate, Glyceryl Linolenate, Retinyl Palmitate, Sodium Ascorbyl Phosphate, Ethylhexylglycerin, Sodium Chloride, Sodium Benzoate, Lactic Acid.

Fillerina 12 HA Biorevitalizing Densifying-Filler - Nourishing Film
Aqua, Cyclopentasiloxane, Glycerin, HDI/Trimethylol Hexyllactone Crosspolymer, Polysilicone-11, C30-45 Alkyl Cetearyl Dimethicone Crosspolymer, Dimethicone, Steareth-2, Hydrogenated Lecithin, Xylitol, Butylene Glycol, Steareth-21, Stearic Acid, Limnanthes Alba Seed Oil, Phenoxyethanol, Boron Nitride, Ammonium Acryloyldimethyltaurate/VP Copolymer, Tocopheryl Acetate, Parfum, Sodium Hyaluronate, Benzophenone-4, Sodium Chloride, Ethylhexylglycerin, Hydroxyacetophenone, Lecithin, Benzophenone-3, Allantoin, Pseudoalteromonas Ferment Extract, Butyrospermum Parkii Butter, Silica, Limonene, Sorbitol, Hexyl Cinnamal, Linalool, Acetyl Cysteine, Glutamic Acid, Glutamine, Leucine, Lysine HCl, Methionine, Taurine, Tryptophan, Tyrosine, Caprylyl Glycol, Glyceryl Linoleate, Glyceryl Linolenate, Retinyl Palmitate, Sodium Ascorbyl Phosphate, Coumarin, Arginine, Salicylic
Acid, Citral, Geraniol, Citronellol, Biotin/Folic Acid/Cyanocobalamin/Niacinamide/Pantothenic Acid/Pyridoxine/Riboflavin/Thiamine/Yeast Polypeptide, Glyceryl Caprylate, Acetyl Hexapeptide-30, Propylene Glycol, Sodium Lactate, Pentylene Glycol, PCA, Sodium PCA, Aspartic Acid, Hydrolyzed DNA, Hydrolyzed RNA, Alanine, Glycine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Calcium Chloride, Cupric Chloride, Ferric Chloride, Magnesium Chloride, Manganese
Chloride, Zinc Chloride, BHT, Xanthan Gum, Alcohol, Disodium EDTA, Sodium Hydroxide.

Pre-Fillerina Skin Preparatory Cleanser
Aqua, Glycerin, Glyceryl Stearate SE, Cetearyl Alcohol, Cocamidopropyl Betaine, Tea-Lauryl Sulfate, Caprylic/Capric Triglyceride, Cetearyl Isononanoate, Glyceryl Stearate, Sucrose
Laurate, Phenoxyethanol, Caprylyl Glycol, Polyacrylamide, Tocopheryl Acetate, C13-14 Isoparaffin, Parfum, Sodium Hyaluronate, Disodium EDTA, Laureth-7, Tributyl Citrate, Tris(Tetramethylhydroxypiperidinol) Citrate, Sodium Benzotriazolyl Butylphenol Sulfonate, Alcohol, Buteth-3, Limonene.

The active ingredients of Labo products may be subject to possible modifications. For an updated version, before using the product, read the list of ingredients on the package.

Technology

TRANSDERMIC TECHNOLOGY

The skin is hardly permeable. In order for Fillerina Hyaluronic Acids and functional molecules to penetrate the different cutaneous layers, Labo researchers developed a Transdermic Technology based on the very low molecular weight of the active substances. This is the fundamental condition to guarantee their penetration exclusively in the skin layers. It is precisely thanks to this controlled penetration that the active ingredients are really effective.

The percentages reported here above refer to the transdermic penetration of the Hyaluronic Acids and of the functional active molecules, in solution, after 24 hours. Transdermic penetration was made possible by new Labo technology and tested by means of Franz Cells.

ACTIVE INGREDIENTS PENETRATION TABLE - TEST WITH FRANZ CELLS

Hyaluronic Acid Monomer 0.4K Da

104.47%

Sodium Hyaluronate 0.8K Da

105.84%

Hyaluronic Acid 1K Da

96.98%

Hydrolyzed Sodium Hyaluronate 5K Da

105.35%

Sodium Hyaluronate 20K Da

105.80%

Hydrolyzed Hyaluronic Acid 50K Da

104.03%

Sodium Hyaluronate 80K Da

100.20%

Sodium Hyaluronate 100K Da

69.20%

Sodium Hyaluronate 200K Da

55.65%

Sodium Hyaluronate 500K Da

55.20%

Sodium Hyaluronate 2000K Da

39.93%

Sodium Hyaluronate Crosspolymer

27.36%

Hydrolyzed Collagen 2K Da

101.30%

Hydrolyzed Collagen 12K Da

95.50%

Soluble Collagen 300K Da

74.60%

Hydrolyzed Elastin 1.4K Da

98.38%

Hydrolyzed Elastin 2.2K Da

97.06%

Palmitoyl Tripeptide-38 (Matrifull)

74.90%

Acetyl Hexapeptide-37

83.20%

Chondroitin Sulfate

80.86%

Effectiveness

FILLERINA EFFICACY TESTS

In 14 days, the 12 Hyaluronic Acids contained in Fillerina play their fundamental action for skin filling and volumisation by performing a FILLER effect on skin depressions (wrinkles, furrows and sagging facial features), and on the areas to be intensified such as cheekbones and lips.

Ex vivo and in vivo efficacy tests demonstrate the excellent results that can be reached with the application of hyaluronic acid molecules, capable to penetrate the skin by passing through the skin layers thanks to their diversified molecular weights.

In particular, the in vivo study on Fillerina, carried out on 40 women under double-blind, placebo-controlled conditions, was the subject of a scientific publication in the authoritative JOURNAL OF COSMETIC DERMATOLOGY, published by Wiley, one of the most important international scientific publishers. This magazine is the official agency of the International Academy of Cosmetic Dermatology based in Philadelphia, USA.

THE RESULTS OF THE CLINICAL-INSTRUMENTAL STUDY

Wrinkle Depth Reduction

The treatment with Fillerina active products determines a reduction equal to -8.4%, -14.5% and -21.8% in wrinkle depth, respectively after 7, 14 and 30 days of treatment. 95% of the subjects had positive results at 14 and 30 days.

Wrinkle Depth Reduction

Average result: -21.8%; Maximum result: -54.8%.

Wrinkle Volume Reduction

The treatment with Fillerina active products results in an average reduction in wrinkle volume equal to -11.3%, -18.4% and -26.3% respectively after 7, 14 and 30 days of treatment. 95% of the subjects had positive results at 14 and 30 days.

Wrinkle Volume Reduction

Average result: -26.3%; Maximum result: -48.1%.

Increase in Cheekbones Volume

The data measure the variation in the distance between the contours of the cheekbones and a line passing through the nose, expressed in millimeters.

Increase in Cheekbones Volume

Average result: +2.27 mm; Maximum result: +3.39 mm.

Lifting of the Cheekbones

The Lifting of the Cheekbones measures the reduction in the distance between the contours of the cheekbones and a horizontal line intersecting the eyes, and is expressed in millimeters.

Lifting of the Cheekbones

Average result: -2.51 mm; Maximum result: -3.67 mm.

Lifting of the Facial Features

The data measure the distance between the upper part (forehead) and the lower part of the face (jaw) in 5 points and are expressed in millimeters. Negative number = reduction in the distance = remodeling action on the oval of the face.

Lifting of the Facial Features

Average result: -1.32 mm; Maximum result: -2.87 mm.

Increase in Lip Volume

The plumping effect on the lips has been calculated based on the mathematical interpolation of the following parameters: 1) length of the labial rim, 2) height of the upper lip and 3) height of the lower lip.

Increase in Lip Volume

Average result: +14.2%; Maximum result: +44.7%.

How to use

HOW TO USE

Fillerina 12HA Biorevitalizing Densifying-Filler Intensive Treatment shall be used every day for 14 days, in the morning or evening, depending on individual needs and habits.
To promote Fillerina action, it is recommended to apply the product on clean skin, free from sebum and impurities.


1. Thanks to the special Dispenser/Applicator it is possible to draw up a total of 2 ml of gel and accurately release it onto the desired areas.
2. Leave it to work for 10 minutes without performing rotating massages or movements.
3. Using the palm of the hands or fingers, pat in the remaining product to complete the application.
4. Draw up 1 – 2 ml of Nourishing Film, as required, and apply it all over face and neck.


Before applying Fillerina 12HA Biorevitalizing Densifying-Filler Treatment, it is necessary to prepare the skin with the special skin preparatory cleanser to be used with the exclusive Pre-Fillerina Brush provided with the box. Apply a walnut-sized amount of Pre-Fillerina on dry skin, and spread it all over the face. Moisten Pre-Fillerina brush and massage the cleanser with circular movements up to producing a soft foam. Insist on particularly difficult areas (T-zone, cheekbones, etc.). Rinse with warm water and dry carefully. Pre-Fillerina Skin Preparatory Cleanser is SLES-free and soap-free. It is suitable for a daily deep cleansing of the face.

Warnings: for external use only. Dermo-cosmetic treatment. Avoid contact with the eyes. Do not swallow. Do not inject. Keep out of the reach of children. Keep away from light and heat.

Patents

SWISS PATENT CH 705 713

Fast-penetration cosmetic dermal filler for topical application.

SWISS PATENT CH 695 412 A5

Graduated cosmetic precision applicator with truncated tip.

SWISS PATENT CH 711 466

Dermo-cosmetic product for topical application with penetration enhancing properties and process for its production.

SWISS PATENT CH 711 092

Biorevitalizing Complex

Frequent questions

Can I use Fillerina treatment on mouth's higher lip wrinkles too?

Fillerina is particularly indicated to fill expression lines: vertical wrinkles on the lips are small expression lines, which can be filled up by Fillerina Gel Filler. Its hyaluronic acids will fill the empty spaces caused by wrinkles, which will progressively appear less marked. Regarding the specific zone of lip contour, we also suggest to use Fillerina Lips & Mouth.

Can I undergo a facial cleasing or get a sunlamp during the treatment?

Sunlamps are extremely stressful for our skin, which consequently will be more inclined to dehydration and wrinkles formation. This is why, in order to promote Fillerina’s best cosmetic results, we advise not to undergo sunlamps. A frequent facial cleansing, instead, can support the deep penetration of hyaluronic acids into the skin and Fillerina’s positive effects, as the skin will be free from impurities and an excess of sebum.

Can I use Fillerina during pregnancy or breastfeeding?

Fillerina can be used during pregnancy and breastfeeding.

How old should I be to start using Fillerina?

Fillerina is a dermo-cosmetic filler treatment that can fill the wrinkles and give more volume to those areas of the face that, with the passing of time, are more subject to emptyings and, consequently, to skin sagging. For this reason, therefore, the product is suitable for people whose skin presents such kind of beauty imperfections. It is hard to fix a precise age; indicatively, it can be used since the age of 25-30.

Can I sunbathe during the treatment?

After Fillerina application you can sunbathe, it being understood that a long exposure requires the application of a suntan cream containing specific and appropriate UV protective filters and in line with your own phototype (for these needs, you can refer to our Fillerina Sun Beauty line or to the Labo Transdermic Sunscreen Fluid Base SPF 50+).

What happens if my applications of Fillerina treatment are not constant?

It is important to follow the treatment schedule and the advised conditions of use. An inconstant application of Fillerina could frustrate the awaited results.

How does the organism assimilate Fillerina?

In the course of time, skin cells metabolize Fillerina’s active ingredients, i.e. its hyaluronic acids, and use them in order to guarantee their filling action. Hyaluronic acid molecules are able to bind water molecules and to promote a progressive filling action of the skin tissue.

Could the treatment cause allergies? Does it contain nickel?

Fillerina contains only tested cosmetic ingredients, so, if you follow our recommended conditions of use, it will not cause any kind of problem. Of course, as it is a cosmetic product, we cannot totally exclude the presence of nickel: a minimal quantity of it is technically unavoidable and it usually does not provoke any kind of problem. In case of nickel allergy, we recommend the application of a small quantity of product on the internal part of the forearm or behind the ear in order to check a possible cutaneous reaction.

How should I preserve the products during the treatment?

Once opened, Fillerina Gel and Nourishing Film should be room-temperature stored, inside their original bottles, which should be closed by means of the provided tips.

Can I use Fillerina treatment on neck and cleavage too?

Fillerina Face Treatment supports the filling action on expression lines and age wrinkles of specific areas of the face, cheekbones and oval contour. If necessary, it can be used on neck and cleavage too. However, for this specific area affected by wrinkles and collapse, Labo created Fillerina Neck and Cleavage.

Why is it important to drink at least two glasses of water before the application?

Hyaluronic acid filling properties are linked to its capability to bind water molecules in the tissues. The larger the quantity of water that the hyaluronic acid binds, the more effective its capability to plump up tissues will be: this way it will fill wrinkles and empty areas of the face. By providing water to the organism, we provide water to cutaneous tissues too: this presence will be captured by Fillerina hyaluronic acid.

What do the product's different grades stand for? how to choose the most suitable one?

Fillerina’s different grades indicate different concentrations of active ingredients and the consumer will have the possibility of choosing which treatment fits best to his personal conditions concerning skin depressions (wrinkles) and volume needs (cheekbones, lips, breasts). In order to choose the most suitable grade for your needs, beyond the pharmacist's advice, Labo's experts suggest referring to the photographic scale of the 3 diversified concentrations published on the Fillerina range page.

What is the correct Fillerina method of use?

The intensive Fillerina Gel + Nourishing Film treatment is distributed on the face and neck using the patented precision applicator with a truncated end. The method of use is reported in the package leaflet as well as the various phases of Fillerina treatments.

How much time does the treatment last? What happens at the end of the treatment? Can I repeat the treatment?

Fillerina filler treatment must be used every day for 14 days. Fillerina is a cosmetic treatment based on hyaluronic acids with different molecular weights, which helps fill wrinkles, expression lines and empty areas of the face. Because of its specific nature – it is a cosmetic treatment for topical use – its effects are temporary. If you wish to maintain the achieved results, we recommend to repeat the treatment every 3-4 months. Between a cycle and the other, you can apply Fillerina Day and Night Creams.

Are there contraindicions for the use of Fillerina treatment on a skin subject to acne?

If your skin presents sebum and acne, it is advisable to apply a gentle face cleanser before Fillerina application. Our Fillerina Biorevitalizing line contains Pre-Fillerina, a specific skin cleanser for the face cleansing.

How to choose the Fillerina Breast Volume dosage?

Fillerina Breast Volume is available in different concentrations of active molecules with dosages corresponding to different types of needs. Generally for small breasts, Labo experts recommend grades 3 or 4; for an emptied breast grade 4 or 5; for breasts with ptosis (accentuated lowering) the recommended grade is 5.
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